What is the difference between drug-induced lupus (DIL) and systemic lupus?

Drug induced lupus (DIL) is reversible when the drug use is discontinued, symptoms of DIL do not include CNS involvement or kidney’s.

What drugs are most commonly associated with DIL?

There is a list of 5 Medications which are associated with DIL they include the following:

Procainamide (pro-can-a-mide) brand names Procan or Pronestyl used for heart rhythm abnormalities

Hydralazine (hi-dral-a-zine) brand name Apresoline or Apresazide used for high blood pressure

Isoniazid (i-so-nye-a-zid) brand name INH used for tuberculosis

Quinidine (quin-i-dean) used for heart rhythm abnormalities

Phenytoin, brand name Dilantin used for convulsive disorders (seizures).

Are there other drugs that might cause DIL?

DIL is associated with other drugs but there is no definite proof of association with DIL yet.  If you are taking any medications this could explain your symptoms that you are experiencing.

Should people diagnosed with SLE or Cutaneous lupus avoid taking the drugs associated with drug-induced Lupus?

People that have SLE or Cutaneous Lupus can use drugs that are associated with DIL safely when there are no other suitable alternatives.

How soon after taking the drug do the symptoms appear?

Symptoms usually take months to years to appear with DIL

How soon after discontinuing the drug will the symptoms go away?

Symptoms usually fade away after six month time period, but this can vary from days, months, to years depending on the individual.  ANA remain positive for years.

 

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